Blar i forfatter "Kostenko, Sergiy Viktorovich"

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    • The diterpenoid alkaloid noroxoaconitine is a Mapkap kinase 5 (MK5/PRAK) inhibitor 

      Kostenko, Sergiy Viktorovich; Khan, Mahmud Tareq Hassan; Sylte, Ingebrigt; Moens, Ugo (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      The mitogen-activated protein kinase-activated protein kinase MK5 is ubiquitously expressed in vertebrates and is implicated in cell proliferation, cytoskeletal remodeling, and anxiety behavior. This makes MK5 an attractive drug target. We tested several diterpenoid alkaloids for their ability to suppress MK5 kinase activity. We identified noroxoaconitine as an ATP competitor that inhibited the ...

    • Septin 8 is an interaction partner and in vitro substrate of MK5. 

      Shiryaev, Alexey; Kostenko, Sergiy Viktorovich; Dumitriu, Giania Aurica; Moens, Ugo (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
      To identify novel substrates for the mitogen-activated protein kinase-activated protein kinase 5 (MK5). Yeast two-hybrid screening with MK5 as bait was used to identify novel possible interaction partners. The binding of putative partner was further examined by glutathione S-transferase (GST) pull-down, co-immunoprecipitation and fluorescence resonance energy transfer (FRET) analysis. In vitro kinase ...

    • Serine residue 115 of MAPK-activated protein kinase MK5 is crucial for its PKA-regulated nuclear export and biological function. 

      Kostenko, Sergiy Viktorovich; Shiryaev, Alexey; Gerits, Nancy; Dumitriu, Gianina Aurica; Klenow, Helle Bagterp; Johannessen, Mona; Moens, Ugo (Journal article; Tidsskriftartikkel; Peer reviewed, 2010)

    • Tumour promoting and suppressing roles of the atypical MAP kinase signalling pathway ERK3/4-MK5. 

      Kostenko, Sergiy Viktorovich; Dumitriu, Giania Aurica; Moens, Ugo (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
      Perturbed action of signal transduction pathways, including the mitogen-activated protein (MAP) kinase pathways, is one of the hallmarks of many cancers. While the implication of the typical MAP kinase pathways ERK1/2-MEK1/2, p38MAPK and JNK is well established, recent findings illustrate that the atypical MAP kinase ERK3/4-MK5 may also be involved in tumorigenic processes. Remarkably, the ERK3/4-MK5 ...